|
|
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+
|
3.5.4.9
methenyltetrahydrofolate cyclohydrolase
|
–
|
| |
BRENDA:
BR22746
KEGG:
R01655
MetaCyc:
METHENYLTHFCYCLOHYDRO-RXN
SABIO-RK:
74
|
|
|
|
L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O
|
2.1.2.1
glycine hydroxymethyltransferase
|
–
|
| |
BRENDA:
BR40573
KEGG:
R00945
MetaCyc:
GLYOHMETRANS-RXN
SABIO-RK:
95
|
|
|
|
5-formyltetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
| |
BRENDA:
BR127;
BS453763
KEGG:
R02301
MetaCyc:
5-FORMYL-THF-CYCLO-LIGASE-RXN
SABIO-RK:
2263
|
|
|
|
glycine + tetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
|
1.4.1.f
1.4.4.2
glycine dehydrogenase (aminomethyl-transferring)
1.8.1.4
dihydrolipoyl dehydrogenase
2.1.2.10
aminomethyltransferase
|
–
–
–
–
|
| |
KEGG:
R01221
MetaCyc:
GCVMULTI-RXN
SABIO-RK:
1451
|
|
|
|
tetrahydrofolate + ATP + formate <=> 10-formyltetrahydrofolate + ADP + phosphate
|
6.3.4.3
formate---tetrahydrofolate ligase
|
–
|
| |
BRENDA:
BR140;
BS443140
KEGG:
R00943
MetaCyc:
FORMATETHFLIG-RXN
SABIO-RK:
51
|
|
|
|
tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH + H+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
1.5.1.34
6,7-dihydropteridine reductase
1.5.1.50
dihydromonapterin reductase
|
–
–
–
–
|
| |
BRENDA:
BR36900
KEGG:
R00939
MetaCyc:
DIHYDROFOLATEREDUCT-RXN;
RXN-19329
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate
|
2.1.1.45
thymidylate synthase
|
–
|
| |
BRENDA:
BR43900;
BS319728
KEGG:
R02101
MetaCyc:
THYMIDYLATESYN-RXN
SABIO-RK:
88
|
|
|
|
5-methyltetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + H+ + NADH
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
| |
BRENDA:
BR36896-a
KEGG:
R07168
MetaCyc:
1.5.1.20-RXN
SABIO-RK:
9210
|
|
|
|
5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
| |
BRENDA:
BR36902;
BS454753
KEGG:
R01220
MetaCyc:
METHYLENETHFDEHYDROG-NADP-RXN
SABIO-RK:
73
|
|
|
|
5,10-methenyltetrahydrofolate + H2O <=> 5-formyltetrahydrofolate + H+
|
2.1.2.10
aminomethyltransferase
3.5.4.9
methenyltetrahydrofolate cyclohydrolase
|
–
–
|
| |
BRENDA:
BS372118
KEGG:
R02300
MetaCyc:
RXN-6321
SABIO-RK:
2262
|
|
|
|
L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate
|
2.1.1.13
methionine synthase
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
–
|
| |
BRENDA:
BR40552
KEGG:
R00946
MetaCyc:
HOMOCYSMETB12-RXN
SABIO-RK:
1260
|
|
